A research group including Professor Kim Ki-Moon of the Department of Chemistry, Lee Don-Wook (Ph.D. candidate), Professor Ryu Sung-Ho of the Division of Molecular and Life Science at POSTECH and NOVACELL Technology, a Bio-Venture, has succeeded in separating cell membrane proteins from a cell using a 'cucurbituril', a pumpkin-shaped coreless compound.
The result was published in the latest online edition of Nature Chemistry. The study finds that using a cucurbituril has many advantages over the commonly used avidin-biotin pair system in extracting plasma membrane proteins for disease analysis.
The new method developed by the research group at POSTECH uses a cucurbituril-ferrocene pair system to selectively isolate plasma membrane proteins from their cells. It is shown to be more efficient in capturing membrane proteins with a much lower possibility of potential contamination.
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